![]() ![]() At the beginning and at the end of treatment usual laboratory tests were performed. cyclosporine dissolved in seed-oil was applied at 5mg/cm 2. Peeling by US waves was performed for 10 minutes, and methylprednisolone in w/o vehicle was applied (at 0.05mg/cm 2. The drug was applied three-times a week for a 3-month period. Thirty patients (median age: 23.6 years) were divided into 2 subgroups: group A treated by methylprednisolone+LFS group Bīy cyclosporine+LFS. Methylprednisolone ointment and cyclosporine solution were used for treatment of alopecia areata. US waves (25 KHz) were obtained by a sonicator apparatus with a power intensity ranging from 50 to 100 mW/cm 2. System with a sonicator apparatus using low frequency sonophoresis (LFS) at 25 KHz to obtain intradermal delivery. To potentiate the epidermal penetration of the drugs used the study aimed to prove the efficacy of an enhancing delivery Horny layer and stimulate convective movements within the epidermis, facilitating the absorption of the active compounds (transdermalĭelivery). Low (about 1-5 % of applied dose) and, ineffective drug delivery into the skin may be a problem with poor results.Įxperimental studies have shown that ultrasound waves (US) high low frequencies bring about a sort of disaggregation of the Biodisposability of most topical formulations is extremely ![]() To have some depigmenting activity for melasma and solar lentigo. IntroductionĬorticosteroids are actually used successfully for the treatment of alopecia areata. (intradermal delivery), giving better results in the treatment of some cosmetic skin disorders. The study shows that LFS, a notĪggressive tecnique, enhance penetration of topic agents obtaining effects at the level of the epidermis, dermis and appendages Conclusion: This is the first report of sonophoresis at a frequency of 25 KHz in dermatocosmetology. For melasma and solar lentigo the results when the drug application was followedīy LFS, were after 3-month and twice a week application: 75 percent complete depigmentation and 25 percent partial for melasma,Ĥ3 percent total regression and 57 percent partial for solar lentigo. The results were: 57 percent partial regrowth and 29 percent total with methylprednisolone and 33 percent partial regrowthĪnd 34 percent total when cyclosporine was used. For alopecia areata after 36 applications with LFS and 3-month treatment Treated by depigmenting emulsion and LFS application. ![]() In a case-control study 48 women with melasma and 48 with solar lentigo were also Or cyclosporine solution followed by LFS. Thirty patients affected by alopecia areata were treated by application of methylprednisolone Has evaluated the efficacy of low frequency sonophoresis (LFS) at 25KHz produced by a sonicator apparatus for treatment ofĪlopecia areata, melasma and solar lentigo. Melasma and lentigo, though proved effective, have limited effects due to only partial penetration into the skin. Some disaggregation of the horny layer and promoting convective movements within the epidermis. Ultrasound waves (US) have been proposed to facilitate the absoption of active compounds (transdermal delivery) stimulating Pietro SantoiannI, Massimiliano Nino, and Gabriella Calabro Dermatology Online Journal 10 (2): 24 Department of Dermatology, University "Federico II" of Naples, Italy Abstract Intradermal drug delivery by low frequency sonophoresis (25KHz) ![]()
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